Li Ern Yap • Cardiovascular Proteomics

Ms. Li Ern Yap

Education

2019-2022

BSc Biomedical Science
King’s College London

Present Appointment

2024-

Research Technician
National Heart and Lung Institute
Imperial College London
London, UK

Previous Appointments

2022-2023

Research Assistant (Cell Biology)
University of Edinburgh

Organised and conducted experiments independently to produce recombinant proteins using bacterial cell lines
Assisted lab members in purifying and validating antibodies used in immunostaining
Skills involved include PCR, plasmid generation, DNA extraction, Western blotting, and affinity purification
Contributed to general lab management and kept detailed records of experimental work
Maintained lab inventory by co-ordinating purchase requisitions for lab consumables and making chemical reagents
Regularly compiled and presented data from experiments and external research papers at internal lab meetings

Awards & Prizes

2021/22

Final Year Performance Prize and Best Overall Performance Prize in Biomedical Science (King’s College London)

Publications

1	Gutmann C, Stojkovic S, Mayr M. Letter by Gutmann et al Regarding Article, “Circulating MicroRNA-122-5p Is Associated With a Lack of Improvement in Left Ventricular Function After Transcatheter Aortic Valve Replacement and Regulates Viability of Cardiomyocytes Through Extracellular Vesi. *Circulation. 2023 147(4)* : e68–e69. [Full Text] [PubMed] [DOI]
2	Gutmann C, Zelniker TA, Mayr M. SGLT2 inhibitors in heart failure: insights from plasma proteomics. *European Heart Journal*. 2022 : . [Full Text] [PubMed] [DOI]
3	Gutmann C, Mayr M. Circulating microRNAs as biomarkers and mediators of platelet activation. *Platelets. 2022 33(4)* : 512-519. [Full Text] [PubMed] [DOI]
4	Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner T, Mathur A, Mayr M. Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. *Arteriosclerosis, thrombosis, and vascular biology*. 2021 : ATVBAHA-121. [Full Text] [PubMed] [DOI]
5	Gutmann C, Khamina K, Theofilatos K, Diendorfer AB, Burnap S, Nabeebaccus A, Fish M, McPhail M, Schmidt L, Cassel C, Auzinger G. Association of cardiometabolic microRNAs with COVID-19 severity and mortality. *Cardiovascular Research*. 2021 : . [Full Text] [PubMed] [DOI]
6	Sangiao-Alvarellos S, Theofilatos K, Barwari T, Gutmann C, Takov K, Singh B, Juiz-Valiña P, Varela-Rodríguez BM, Outeiriño-Blanco E, Duregotti E, Zampetaki A, Lunger L, Ebenbichler C, Tilg H, García-Brao MJ, Willeit P, Mena E, Kiechl S, Cordido F, Mayr M. Metabolic recovery after weight loss surgery is reflected in serum microRNAs. *BMJ Open Diabetes Research and Care. 2020 8(2)* : e001441. [Full Text] [PubMed] [DOI]
7	Gutmann C, Takov K, Burnap S, Singh B, Theofilatos K, Reed E, Hasman M, Nabeebaccus A, Fish M, McPhail M, O'Gallagher K, Schmidt L, Cassel C, Rienks M, Yin X, Auzinger G, Napoli S, Mujib S, Trovato F, Sanderson B, Merrick B, Niazi U, Saqi M, Dimitrakopoulou K, Braun S, Kronstein-Wiedemann R, Doores K, Edgeworth J, Shah A, Bornstein S, Tonn T, Hayday A, Shankar-Hari M, Mayr M. SARS-CoV-2 RNAemia and proteomic biomarker trajectory inform prognostication in COVID-19 patients admitted to intensive care. . 2020 : . [Full Text] [DOI]
8	Gutmann C, Joshi A, Mayr M. Platelet "-omics" in health and cardiovascular disease. *Atherosclerosis*. 2020 : . [Full Text] [PubMed] [DOI]
9	Gutmann C, Joshi A, Zampetaki A, Mayr M. The Landscape of Coding and Non-coding RNAs in Platelets. *Antioxidants & Redox Signaling*. 2020 : . [Full Text] [DOI]
10	Braza-Boïls A, Barwari T, Gutmann C, Thomas MR, Judge HM, Joshi A, Pechlaner R, Shankar-Hari M, Ajjan RA, Sabroe I, Storey RF, Mayr M. Circulating MicroRNA Levels Indicate Platelet and Leukocyte Activation in Endotoxemia Despite Platelet P2Y12 Inhibition. *Int J Mol Sci. 2020 21(8)* : 2897. [Full Text] [PubMed] [DOI]